Chromatin Regulator | Alias | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CBX5 | HP1;HP1A;HEL25 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External Links: | Wiki GeneCards NCBI UniProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Related histone modifications: | H3K9me3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Introduction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Full name: Chromobox 5. CBX5 is a member of heterochromatin protein 1 (HP1) family,contains two chromodomains including a C-terminal chromodomain which is also known as the chromo shadow domain (CSD)(1).CBX5 recognizes and binds trimethylated lysine 9 on histone H3 which is required for epigentic repression(2-4).CBX5 binds the Y41 region of H3 in a phosphorylation-dependent manner(5). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Function and Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CBX5 recognizes and binds trimethylated H3K9 which is involved in epigentic repression of gene silencing via its chromo domain(1-2).CBX5 guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation(6).CBX5 plays an important role in the differentiation and angiogenic function of EPCs by regulating endothelial gene expression(7).CBX5 interacts with the inner nuclear membrane protein LBR (lamin B receptor),contributes to the association of the heterochromatin with the inner nuclear membrane(8). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Disease Association | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NA | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ChIP-Seq data
ChIP-Seq data of related histone modifications
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| Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 1.Tajul-Arifin, K., Teasdale, R., Ravasi, T., Hume, D.A., Mattick, J.S., Group, R.G., and Members, G.S.L. (2003). Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Genome Res 13, 1416-1429. 2.Jacobs, S.A., Taverna, S.D., Zhang, Y., Briggs, S.D., Li, J., Eissenberg, J.C., Allis, C.D., and Khorasanizadeh, S. (2001). Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J 20, 5232-5241. 3.Bartke, T., Vermeulen, M., Xhemalce, B., Robson, S.C., Mann, M., and Kouzarides, T. (2010). Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143, 470-484. 4.Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001). Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120. 5.Dawson, M.A., Bannister, A.J., Gottgens, B., Foster, S.D., Bartke, T., Green, A.R., and Kouzarides, T. (2009). JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822. 6.Panteleeva, I., Boutillier, S., See, V., Spiller, D.G., Rouaux, C., Almouzni, G., Bailly, D., Maison, C., Lai, H.C., Loeffler, J.P., et al. (2007). HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J 26, 3616-3628. 7.Maeng, Y.S., Kwon, J.Y., Kim, E.K., and Kwon, Y.G. (2015). Heterochromatin Protein 1 Alpha (HP1alpha: CBX5) is a Key Regulator in Differentiation of Endothelial Progenitor Cells to Endothelial Cells. Stem Cells 33, 1512-1522. 8.Ye, Q., Callebaut, I., Pezhman, A., Courvalin, J.C., and Worman, H.J. (1997). Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. J Biol Chem 272, 14983-14989. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Figure Gallery
About Chromatin Regulator
Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.