CR Name:
Species:    Tissue or Cell: 

Chromatin Regulator

Alias

RBBP5RBQ3;SWD1

External Links:

Wiki    GeneCards    NCBI    UniProt

Related histone modifications:

H3K4me1;H3K4me2;H3K4me3

Introduction

Full name: RB Binding Protein 5. RBBP5 is a core component of human mixed lineage leukemia protein-1 (MLL1) which is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute leukemias,is involved in mono-,di- and trimethylation at Lys-4 of histone H3(1-4).RBBP5 interacts with MOF as a component of MLL1 to form a complex which both have a robust MLL1-mediated histone methyltransferase activity that can affect mono-,di-,and trimethylation of H3K4 and a MOF-mediated histone acetyltransferase activity that is specific for H4K16(2).

Function and Interaction

RBBP5 is an essential component of the MLL complex,is involved in mono-,di- and trimethylation on histone H3K4,is required for maintenance of Hox gene expression(1-4).RBBP5 is involved in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell(5).RBBP5 is required for DNA replication as a member of the MLL-WDR5-RBBP5 methyltransferase complex that transfer methyl groups to histone at K4(H3K4),suppress DNA re-replication and chromosomal polyploidy(6).

Disease Association

NA

ChIP-Seq data


SpeciesCell lineCell typeTissueDataDownloadSend to CistromeAnalysis FiguresComparisonReference
Homo sapiensK562ErythroblastBone MarrowGSE32509 ,GSM831012
Click  DownloadClick22196736

ChIP-Seq data of related histone modifications


Products/SubstratesSpeciesCell lineCell typeTissueDataDownload Send to CistromeAnalysis FiguresReference
H3K4me3 Homo sapiens H1 Embryonic Stem Cell Embryo GSE41009 ,GSM1006722 Bed     Big wiggle
Click   Download23382218
H3K4me3 Mus musculus CMTi-1 Embryonic Stem Cell Embryo GSE34483 ,GSM1047934 Bed     Big wiggle
Click   Download23260488
H3K4me1 Mus musculus None Embryonic Stem Cell Embryo GSE47950 ,GSM1163084 Bed     Big wiggle
Click   Download22981692
H3K4me1 Mus musculus None Embryonic Stem Cell Embryo GSE47950 ,GSM1163085 Bed     Big wiggle
Click   Download22981692
H3K4me1 Mus musculus None Embryonic Stem Cell Embryo GSE47950 ,GSM1163086 Bed     Big wiggle
Click   Download22981692
H3K4me3 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE48172 ,GSM1171628 Bed     Big wiggle
Click   Download23934151
H3K4me3 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE48172 ,GSM1171630 Bed     Big wiggle
Click   Download23934151
H3K4me3 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE48172 ,GSM1171632 Bed     Big wiggle
Click   Download23934151
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE52071 ,GSM1258237 Bed     Big wiggle
Click   Download24423662
H3K4me3 Mus musculus None Embryonic Stem Cell Embryo GSE52071 ,GSM1276704 Bed     Big wiggle
Click   Download24423662
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE52071 ,GSM1276705 Bed     Big wiggle
Click   Download24423662
H3K4me1 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282133 Bed     Big wiggle
Click   Download24495580
H3K4me1 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282134 Bed     Big wiggle
Click   Download24495580
H3K4me3 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282137 Bed     Big wiggle
Click   Download24495580
H3K4me2 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282138 Bed     Big wiggle
Click   Download24495580
H3K4me3 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282139 Bed     Big wiggle
Click   Download24495580
H3K4me2 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282140 Bed     Big wiggle
Click   Download24495580
H3K4me1 Mus musculus R1 Embryonic Stem Cell Embryo GSE53087 ,GSM1282147 Bed     Big wiggle
Click   Download24495580
H3K4me1 Homo sapiens H1 Embryonic Stem Cell Embryo GSE57989 ,GSM1399262 Bed     Big wiggle
Click   Download24879559
H3K4me1 Homo sapiens H1 Embryonic Stem Cell Embryo GSE57989 ,GSM1399263 Bed     Big wiggle
Click   Download24879559
H3K4me3 Mus musculus XT67E1 Embryonic Stem Cell Embryo GSE15884 ,GSM397402 Bed     Big wiggle
Click   Download19581487
H3K4me3 Mus musculus XT67E1 Embryonic Stem Cell Embryo GSE15884 ,GSM397403 Bed     Big wiggle
Click   Download19581487
H3K4me3 Mus musculus XT67E1 Embryonic Stem Cell Embryo GSE15884 ,GSM397404 Bed     Big wiggle
Click   Download19581487
H3K4me3 Mus musculus C6 Embryonic Stem Cell Embryo GSE16893 ,GSM487545 Bed     Big wiggle
Click   Download20211137
H3K4me3 Mus musculus C6 Embryonic Stem Cell Embryo GSE16893 ,GSM487548 Bed     Big wiggle
Click   Download20211137
H3K4me3 Mus musculus TNGA Embryonic Stem Cell Embryo GSE23943 ,GSM590110 Bed     Big wiggle
Click   Download22541430
H3K4me3 Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM605315 Bed     Big wiggle
Click   Download19829295
H3K4me3 Homo sapiens K562 Erythroblast Bone Marrow GSE28162 ,GSM608165 Bed     Big wiggle
Click   Download21596310
H3K4me1 Homo sapiens K562 Erythroblast Bone Marrow GSE24779 ,GSM610339 Bed     Big wiggle
Click   Download20959602
H3K4me2 Mus musculus None Embryonic Stem Cell Embryo GSE25533 ,GSM632035 Bed     Big wiggle
Click   Download22179133
H3K4me2 Homo sapiens H1 Embryonic Stem Cell Embryo GSE26320 ,GSM646343 Bed     Big wiggle
Click   Download21441907
H3K4me2 Homo sapiens H1 Embryonic Stem Cell Embryo GSE26320 ,GSM646344 Bed     Big wiggle
Click   Download21441907
H3K4me2 Homo sapiens K562 Erythroblast Bone Marrow GSE26320 ,GSM646442 Bed     Big wiggle
Click   Download21441907
H3K4me2 Homo sapiens K562 Erythroblast Bone Marrow GSE26320 ,GSM646443 Bed     Big wiggle
Click   Download21441907
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE26136 ,GSM651193 Bed     Big wiggle
Click   Download21335234
H3K4me2 Mus musculus None Embryonic Stem Cell Embryo GSE33252 ,GSM686995 Bed     Big wiggle
Click   Download21655081
H3K4me1 Mus musculus ZhBTc4 Embryonic Stem Cell Embryo GSE27844 ,GSM687286 Bed     Big wiggle
Click   Download22297846
H3K4me1 Mus musculus ZhBTc4 Embryonic Stem Cell Embryo GSE27844 ,GSM687287 Bed     Big wiggle
Click   Download22297846
H3K4me1 Mus musculus ZhBTc4 Embryonic Stem Cell Embryo GSE27844 ,GSM687288 Bed     Big wiggle
Click   Download22297846
H3K4me2 Homo sapiens K562 Erythroblast Bone Marrow GSE29611 ,GSM733651 Bed     Big wiggle
Click   Download22955616
H3K4me2 Homo sapiens H1 Embryonic Stem Cell Embryo GSE29611 ,GSM733670 Bed     Big wiggle
Click   Download22955616
H3K4me1 Homo sapiens K562 Erythroblast Bone Marrow GSE29611 ,GSM733692 Bed     Big wiggle
Click   Download22955616
H3K4me2 Mus musculus None Embryonic Stem Cell Embryo GSE30203 ,GSM747544 Bed     Big wiggle
Click   Download22170606
H3K4me1 Homo sapiens K562 Erythroblast Bone Marrow GSE31755 ,GSM788085 Bed     Big wiggle
Click   Download25409831
H3K4me1 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE27844 ,GSM845238 Bed     Big wiggle
Click   Download22297846
H3K4me1 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE27844 ,GSM845239 Bed     Big wiggle
Click   Download22297846
H3K4me1 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE27844 ,GSM845243 Bed     Big wiggle
Click   Download22297846
H3K4me3 Mus musculus CMTi-1 Embryonic Stem Cell Embryo GSE34483 ,GSM849932 Bed     Big wiggle
Click   Download23260488
H3K4me3 Mus musculus CMTi-1 Embryonic Stem Cell Embryo GSE34483 ,GSM849941 Bed     Big wiggle
Click   Download23260488
H3K4me3 Homo sapiens K562 Erythroblast Bone Marrow GSE35294 ,GSM865280 Bed     Big wiggle
Click   Download23754963
H3K4me3 Homo sapiens K562 Erythroblast Bone Marrow GSE35294 ,GSM865281 Bed     Big wiggle
Click   Download23754963
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881353 Bed     Big wiggle
Click   Download22682255
H3K4me1 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881360 Bed     Big wiggle
Click   Download22682255
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881361 Bed     Big wiggle
Click   Download22682255
H3K4me1 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881369 Bed     Big wiggle
Click   Download22682255
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881370 Bed     Big wiggle
Click   Download22682255
H3K4me3 Mus musculus R1 Embryonic Stem Cell Embryo GSE36294 ,GSM886518 Bed     Big wiggle
Click   Download24381111
H3K4me2 Mus musculus R1 Embryonic Stem Cell Embryo GSE36294 ,GSM886531 Bed     Big wiggle
Click   Download24381111
H3K4me1 Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM906403 Bed     Big wiggle
Click   Download19829295
H3K4me3 Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM906405 Bed     Big wiggle
Click   Download19829295
H3K4me3 Mus musculus TC1 Embryonic Stem Cell Embryo GSE37776 ,GSM928131 Bed     Big wiggle
Click   Download22666422
H3K4me3 Mus musculus 3.2N Embryonic Stem Cell Embryo GSE37776 ,GSM928132 Bed     Big wiggle
Click   Download22666422
H3K4me3 Mus musculus None Embryonic Stem Cell Embryo GSE39472 ,GSM969829 Bed     Big wiggle
Click   Download22826230
H3K4me3 Mus musculus None Embryonic Stem Cell Embryo GSE39472 ,GSM969830 Bed     Big wiggle
Click   Download22826230
H3K4me1 Mus musculus E36 Embryonic Stem Cell Embryo GSE39496 ,GSM970225 Bed     Big wiggle
Click   Download24289921
H3K4me1 Mus musculus E36 Embryonic Stem Cell Embryo GSE39496 ,GSM970226 Bed     Big wiggle
Click   Download24289921
H3K4me3 Mus musculus E36 Embryonic Stem Cell Embryo GSE39496 ,GSM970227 Bed     Big wiggle
Click   Download24289921
H3K4me3 Mus musculus E36 Embryonic Stem Cell Embryo GSE39496 ,GSM970228 Bed     Big wiggle
Click   Download24289921

Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial.

References

1.Patel, A., Dharmarajan, V., Vought, V.E., and Cosgrove, M.S. (2009). On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem 284, 24242-24256.
2.Dou, Y., Milne, T.A., Tackett, A.J., Smith, E.R., Fukuda, A., Wysocka, J., Allis, C.D., Chait, B.T., Hess, J.L., and Roeder, R.G. (2005). Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121, 873-885.
3.Yokoyama, A., Wang, Z., Wysocka, J., Sanyal, M., Aufiero, D.J., Kitabayashi, I., Herr, W., and Cleary, M.L. (2004). Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol 24, 5639-5649.
4.Dehe, P.M., Dichtl, B., Schaft, D., Roguev, A., Pamblanco, M., Lebrun, R., Rodriguez-Gil, A., Mkandawire, M., Landsberg, K., Shevchenko, A., et al. (2006). Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation. J Biol Chem 281, 35404-35412.
5.Li, D., Sun, H., Sun, W.J., Bao, H.B., Si, S.H., Fan, J.L., Lin, P., Cui, R.J., Pan, Y.J., Wen, S.M., et al. (2016). Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell. Oncotarget 7, 65553-65567.
6.Lu, F., Wu, X., Yin, F., Chia-Fang Lee, C., Yu, M., Mihaylov, I.S., Yu, J., Sun, H., and Zhang, H. (2016). Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open 5, 1449-1460.

Figure Gallery

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About Chromatin Regulator

Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.

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