CR Name:
Species:    Tissue or Cell: 

Chromatin Regulator

Alias

CREBBPCBP;KAT3A;RSTS1;RSTS

External Links:

Wiki    GeneCards    NCBI    UniProt

Related histone modifications:

H3K27ac;H4K16ac;H4K12ac;H4K8ac;H4K5ac;H3K18ac;H3K56ac

Introduction

Full name: cAMP-response element binding protein (CREB) binding protein. CREBBP is a large protein consisting of over 2400 amino acids,is first isolated as a nuclear protein that binds to cAMP-response element binding protein(CREB),shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain,has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interaction with the transcription complex(1-2).CREBBP plays critical roles in embryonic development, growth control, and homeostasis(1-7).

Function and Interaction

CREBBP has intrinsic histone acetyltransferase activity towards H3 and H4(1-2).CREBBP is known to interact with a variety of DNA-binding transcriptional factors including nuclear hormone receptors,CREB,c-Jun/v-Jun,c-Myb/v-Myb,Sap-1a,c-Fos and MyoD,binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes,acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators:NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers(3-8).Acetylation activity of CREBBP promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair(NER)(9).

Disease Association

CREBBP is associated with Rubinstein-Taybi syndrome,which is characterized by facial abnormalities, broad thumbs, large toes, and mental retardation(10).

ChIP-Seq data


SpeciesCell lineCell typeTissueDataDownloadSend to CistromeAnalysis FiguresComparisonReference
Mus musculusNAFibroblastEmbryoGSE54454 ,GSM1315602
Click  DownloadClick25249627

ChIP-Seq data of related histone modifications


Products/SubstratesSpeciesCell lineCell typeTissueDataDownload Send to CistromeAnalysis FiguresReference
H3K27ac Homo sapiens DND-41 T Lymphocyte Blood GSE29611 ,GSM1003462 Bed     Big wiggle
Click   Download22955616
H3K27ac Homo sapiens NA T Lymphocyte Blood GSE43119 ,GSM1056919 Bed     Big wiggle
Click   Download24671953
H3K27ac Homo sapiens NA T Lymphocyte Blood GSE43119 ,GSM1056920 Bed     Big wiggle
Click   Download24671953
H3K27ac Mus musculus NA Fibroblast Embryo GSE51004 ,GSM1234515 Bed     Big wiggle
Click   Download25043028
H3K27ac Homo sapiens Jurkat T Lymphocyte Blood GSE51522 ,GSM1246865 Bed     Big wiggle
Click   Download24119843
H3K27ac Homo sapiens CUTLL1 T Lymphocyte Blood GSE51800 ,GSM1252938 Bed     Big wiggle
Click   Download24374627
H3K27ac Homo sapiens CUTLL1 T Lymphocyte Blood GSE51800 ,GSM1252939 Bed     Big wiggle
Click   Download24374627
H3K27ac Homo sapiens CUTLL1 T Lymphocyte Blood GSE51800 ,GSM1252940 Bed     Big wiggle
Click   Download24374627
H3K27ac Mus musculus NA Epithelium Liver GSE52386 ,GSM1264390 Bed     Big wiggle
Click   Download24360275
H3K27ac Mus musculus NA Epithelium Liver GSE52386 ,GSM1264394 Bed     Big wiggle
Click   Download24360275
H3K27ac Homo sapiens Jurkat T Lymphocyte Blood GSE50625 ,GSM1296384 Bed     Big wiggle
Click   Download25043025
H3K27ac Mus musculus NA T Lymphocyte Blood GSE53831 ,GSM1301745 Bed     Big wiggle
Click   Download24694524
H3K27ac Mus musculus NA T Lymphocyte Blood GSE53831 ,GSM1301746 Bed     Big wiggle
Click   Download24694524
H3K27ac Homo sapiens KOPT-K1 T Lymphocyte Blood GSE54380 ,GSM1314122 Bed     Big wiggle
Click   Download24584072
H3K27ac Homo sapiens KOPT-K1 T Lymphocyte Blood GSE54380 ,GSM1314129 Bed     Big wiggle
Click   Download24584072
H3K27ac Homo sapiens DND-41 T Lymphocyte Blood GSE54380 ,GSM1314136 Bed     Big wiggle
Click   Download24584072
H3K27ac Homo sapiens DND-41 T Lymphocyte Blood GSE54380 ,GSM1314143 Bed     Big wiggle
Click   Download24584072
H3K27ac Mus musculus NIH-3T3 Fibroblast Embryo GSE58731 ,GSM1418776 Bed     Big wiggle
Click   Download25383670
H3K27ac Mus musculus NIH-3T3 Fibroblast Embryo GSE58731 ,GSM1418777 Bed     Big wiggle
Click   Download25383670
H3K27ac Mus musculus NIH-3T3 Fibroblast Embryo GSE58731 ,GSM1418779 Bed     Big wiggle
Click   Download25383670
H3K27ac Homo sapiens Jurkat T Lymphocyte Blood GSE59257 ,GSM1431909 Bed     Big wiggle
Click   DownloadNA
H3K27ac Mus musculus NA T Lymphocyte Blood GSE60103 ,GSM1441281 Bed     Big wiggle
Click   Download25103404
H3K27ac Mus musculus NA Fibroblast Embryo GSE61434 ,GSM1462936 Bed     Big wiggle
Click   Download25454632
H3K27ac Mus musculus NA Fibroblast Embryo GSE60026 ,GSM1463933 Bed     Big wiggle
Click   DownloadNA
H3K27ac Mus musculus NA Cortical Neuron Neuric GSE60192 ,GSM1467417 Bed     Big wiggle
Click   Download25195102
H3K27ac Mus musculus NA Cortical Neuron Neuric GSE60192 ,GSM1467418 Bed     Big wiggle
Click   Download25195102
H3K27ac Mus musculus NA Cortical Neuron Neuric GSE60192 ,GSM1467419 Bed     Big wiggle
Click   Download25195102
H3K27ac Mus musculus NIH-3T3 Fibroblast Embryo GSE66286 ,GSM1618720 Bed     Big wiggle
Click   Download26446258
H3K27ac Mus musculus NIH-3T3 Fibroblast Embryo GSE66286 ,GSM1618722 Bed     Big wiggle
Click   Download26446258
H4K16ac Mus musculus None Cortical Neuron None GSE66710 ,GSM1629377 Bed     Big wiggle
Click   Download25892301
H4K16ac Mus musculus None Cortical Neuron None GSE66710 ,GSM1629378 Bed     Big wiggle
Click   Download25892301
H3K27ac Mus musculus None Cortical Neuron None GSE66710 ,GSM1629397 Bed     Big wiggle
Click   Download25892301
H3K27ac Mus musculus None Cortical Neuron None GSE66710 ,GSM1629398 Bed     Big wiggle
Click   Download25892301
H3K27ac Homo sapiens K562 Erythroblast Bone Marrow GSE63782 ,GSM1652918 Bed     Big wiggle
Click   Download26367798
H4K16ac Homo sapiens NA T Lymphocyte Blood GSE15735 ,GSM393962 Bed     Big wiggle
Click   Download19698979
H4K16ac Homo sapiens NA T Lymphocyte Blood GSE15735 ,GSM393963 Bed     Big wiggle
Click   Download19698979
H4K16ac Homo sapiens NA T Lymphocyte Blood GSE15735 ,GSM393964 Bed     Big wiggle
Click   Download19698979
H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE24165 ,GSM594578 Bed     Big wiggle
Click   Download21106759
H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE24165 ,GSM594579 Bed     Big wiggle
Click   Download21106759
H3K27ac Mus musculus NA Epithelium Liver GSE24165 ,GSM594587 Bed     Big wiggle
Click   Download21106759
H3K27ac Homo sapiens K562 Erythroblast Bone Marrow GSE26320 ,GSM646434 Bed     Big wiggle
Click   Download21441907
H3K27ac Homo sapiens K562 Erythroblast Bone Marrow GSE29611 ,GSM733656 Bed     Big wiggle
Click   Download22955616
H3K27ac Homo sapiens NA T Lymphocyte Blood GSE17312 ,GSM997233 Bed     Big wiggle
Click   Download20944595

Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial.

References

1.Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, M.R., and Goodman, R.H. (1993). Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
2.Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
3.Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., and Evans, R.M. (1996). Role of CBP/P300 in nuclear receptor signalling. Nature 383, 99-103.
4.Arias, J., Alberts, A.S., Brindle, P., Claret, F.X., Smeal, T., Karin, M., Feramisco, J., and Montminy, M. (1994). Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370, 226-229.
5.Dai, P., Akimaru, H., Tanaka, Y., Hou, D.X., Yasukawa, T., Kanei-Ishii, C., Takahashi, T., and Ishii, S. (1996). CBP as a transcriptional coactivator of c-Myb. Genes Dev 10, 528-540.
6.Janknecht, R., and Nordheim, A. (1996). Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene 12, 1961-1969.
7.Yuan, W., Condorelli, G., Caruso, M., Felsani, A., and Giordano, A. (1996). Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem 271, 9009-9013.
8.Iioka, T., Furukawa, K., Yamaguchi, A., Shindo, H., Yamashita, S., and Tsukazaki, T. (2003). P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain. J Bone Miner Res 18, 1419-1429.
9.Cazzalini, O., Sommatis, S., Tillhon, M., Dutto, I., Bachi, A., Rapp, A., Nardo, T., Scovassi, A.I., Necchi, D., Cardoso, M.C., et al. (2014). CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res 42, 8433-8448.
10.Roelfsema, J.H., White, S.J., Ariyurek, Y., Bartholdi, D., Niedrist, D., Papadia, F., Bacino, C.A., den Dunnen, J.T., van Ommen, G.J.B., Breuning, M.H. et al. (2005) Genetic heterogeneity in Rubinstein-Taybi syndrome: Mutations in both the CBP and EP300 genes cause disease. Am J Hum Genet, 76, 572-580.

Figure Gallery

pix pix pix pix pix pix

About Chromatin Regulator

Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.

Contact

houshuang [at] tongji dot edu dot cn