Chromatin Regulator Cistrome

Chromatin Regulator

Alias

KAT7

HBO1; HBOA; MYST2

External Links:

Wiki GeneCards NCBI UniProt

Related histone modifications:

H4K5ac;H4K12ac;H4K8ac

Introduction

Full Name: MYST histone acetyltransferase 2 . KAT7 is a member of the MYST family of histone acetyltransferases. It acts as an H4-specific histone acetylase and is involved in both transcriptional activation and repression, primarily functioning as a regulator of DNA replication. This protein is also involved in embryonic development and primary cancers (1-6).

Function and Interaction

KAT7 is a coactivator of the replication licensing factor Cdt1. KAT7 can interact directly with Cdt1, thereby enhancing CDT1-dependent re-replication, which can be inhibited by the Cdt1 repressor geminin (1-2). KAT7 is thought to suppress the activity of NF-kappaB in 293T cells through its N-terminal serine-rich region, rather than its acetyltransferase function (5). KAT7 is capable of interacting with the androgen receptor (AR), potentially resulting in the regulation of AR-induced gene expression in normal and cancerous prostate cells (6). KAT7 is believed to act as an upstream regulator in the assembly of the prereplicative complex (pre-RC), which involves the recruitment of origin recognition complex protein (ORC), Cdc6/Cdc18, Cdt1, and the minichromosome maintenance complex (Mcm2-7) to the replication origin, thereby initiating DNA replication. Acetylation by KAT7 is particularly enhanced during the G2/M cell cycle phase (7). Studies have also shown that KAT7 can interact with Fad24 in promoting adipogenesis through the modulation of DNA replication (8). In addition to carrying out the acetylation of lysines 5, 8, and 12 of histone H4, KAT7 is required for H3K14 acetylation, thus acting as a transcriptional activator of the genes involved in embryonic development (9-10).

Disease Association

KAT7 is associated with several types of primary cancers, such as cancers of the testis, ovary, breast, stomach, and bladder (3-4).

ChIP-Seq data

Species	Cell line	Cell type	Tissue	Data	Download	Send to Cistrome	Analysis Figures	Comparison	Reference
Homo sapiens	RKO	Epithelium	Colon	GSE33007 ,GSM818282		Click Download	NA	22144582

ChIP-Seq data of related histone modifications

Products/Substrates	Species	Cell line	Cell type	Tissue	Data	Download	Send to Cistrome	Analysis Figures	Reference

Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial.

References

1. Miotto, B. and Struhl, K. (2008) HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Gene Dev, 22, 2633-2638.
2. Miotto, B. and Struhl, K. (2010) HBO1 Histone Acetylase Activity Is Essential for DNA Replication Licensing and Inhibited by Geminin. Mol Cell, 37, 57-66.
3. Iizuka, M., Takahashi, Y., Mizzen, C.A., Cook, R.G., Fujita, M., Allis, C.D., Frierson, H.F., Fukusato, T. and Smith, M.M. (2009) Histone acetyltransferase Hbo1: Catalytic activity, cellular abundance, and links to primary cancers. Gene, 436, 108-114.
4. Hu, X.L., Stern, H.M., Ge, L., O'Brien, C., Haydu, L., Honchell, C.D., Haverty, P.M., Peters, B.A., Wu, T.D., Amler, L.C. et al. (2009) Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes. Mol Cancer Res, 7, 511-522.
5. Contzler, R., Regamey, A., Favre, B., Roger, T., Hohl, D. and Huber, M. (2006) Histone acetyltransferase HBO1 inhibits NF-kappaB activity by coactivator sequestration. Biochem Biophys Res Commun, 350, 208-213.
6. Sharma, M., Zarnegar, M., Li, X., Lim, B. and Sun, Z. (2000) Androgen receptor interacts with a novel MYST protein, HBO1. J Biol Chem, 275, 35200-35208.
7. Iizuka, M., Matsui, T., Takisawa, H. and Smith, M.M. (2006) Regulation of replication licensing by acetyltransferase Hbo1. Mol Cell Biol, 26, 1098-1108.
8. Johmura, Y., Osada, S., Nishizuka, M. and Imagawa, M. (2008) FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication. J Biol Chem, 283, 2265-2274.
9. Kueh, A.J., Dixon, M.P., Voss, A.K. and Thomas, T. (2011) HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development. Mol Cell Biol, 31, 845-860.
10. Doyon, Y., Cayrou, C., Ullah, M., Landry, A.J., Cote, V., Selleck, W., Lane, W.S., Tan, S., Yang, X.J. and Cote, J. (2006) ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell, 21, 51-64.

Chromatin Regulator Cistrome
A knowledgebase for chromatin modifying enzymes and chromatin remodelers