Chromatin Regulator | Alias | |||||||||||||||||||||||||||||
| KDM2A | FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA | |||||||||||||||||||||||||||||
External Links: | Wiki GeneCards NCBI UniProt | |||||||||||||||||||||||||||||
Related histone modifications: | H3K36me2;H3K36me1 | |||||||||||||||||||||||||||||
Introduction | ||||||||||||||||||||||||||||||
| Full name: Lysine(K)-specific demethylase 2A . KDM2A is a member of the KDM2 Lys histone demethylase family and belongs to the Fbls class, containing leucine-rich repeats in the F-box, and displaying a Jmjc domain, upon which its enzymatic function depends (1-3). KDM2A can specifically regulate the level of H3-K36 mono- and dimethylation by acting as a demethylase (1-2). | ||||||||||||||||||||||||||||||
Function and Interaction | ||||||||||||||||||||||||||||||
| KDM2A is directly recruited by CpG islands through its zinc finger CxxC (ZF-CxxC) domain to remove H3K36 methylation, ensuring that CpG islands can eliminate this type of modification (4). Furthermore, KDM2A is constrained to bind to CpG islands, even in the absence of genome methylation (5). KDM2A can modulate the transcription of ribosomal RNA, which is the rate-limiting step during the biosynthesis of ribosomes, through its dimethyl function (6). KDM2A is also essential for maintaining a heterochromatic status and is related to centromeres and participates in epigenetic silencing (7). Overexpression of KDM2A can lead to the immortalization of mouse embryonic fibroblasts (MEFs) through its Jmjc domain and, possibly, its dimethyl function (8). KDM2A interacts with heterochromatin protein 1 and assists it in localizing to the chromosome (7). | ||||||||||||||||||||||||||||||
Disease Association | ||||||||||||||||||||||||||||||
| The level of KDM2A expression is dramatically reduced in prostate cancers relative to normal prostate cells, which may be the cause of the centromeric rearrangements and mitotic offset in prostate cancer, indicating that this protein plays a role in cancer development (7). Together with Ndy1, KDM2A participates in the initiation and development of T cell lymphomas, which are induced by MoMuLV in rodents (8). | ||||||||||||||||||||||||||||||
ChIP-Seq data
ChIP-Seq data of related histone modifications
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| Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial. | ||||||||||||||||||||||||||||||
References | ||||||||||||||||||||||||||||||
| 1. Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M.E., Borchers, C.H., Tempst, P. and Zhang, Y. (2006) Histone demethylation by a family of JmjC domain-containing proteins. Nature, 439, 811-816. 2. Allis, C.D., Berger, S.L., Cote, J., Dent, S., Jenuwien, T., Kouzarides, T., Pillus, L., Reinberg, D., Shi, Y., Shiekhattar, R. et al. (2007) New nomenclature for chromatin-modifying enzymes. Cell, 131, 633-636. 3. Jin, J.P., Cardozo, T., Lovering, R.C., Elledge, S.J., Pagano, M. and Harper, J.W. (2004) Systematic analysis and nomenclature of mammalian F-box proteins. Gene Dev, 18, 2573-2580. 4. Blackledge, N.P., Zhou, J.C., Tolstorukov, M.Y., Farcas, A.M., Park, P.J. and Klose, R.J. (2010) CpG Islands Recruit a Histone H3 Lysine 36 Demethylase. Mol Cell, 38, 179-190. 5. Zhou, J.C., Blackledge, N.P., Farcas, A.M. and Klose, R.J. (2012) Recognition of CpG Island Chromatin by KDM2A Requires Direct and Specific Interaction with Linker DNA. Mol Cell Biol, 32, 479-489. 6. Tanaka, Y., Okamoto, K., Teye, K., Umata, T., Yamagiwa, N., Suto, Y., Zhang, Y. and Tsuneoka, M. (2010) JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. Embo Journal, 29, 1510-1522. 7. Frescas, D., Guardavaccaro, D., Kuchay, S.M., Kato, H., Poleshko, A., Basrur, V., Elenitoba-Johnson, K.S., Katz, R.A. and Pagano, M. (2008) KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle, 7, 3539-3547. 8. Pfau, R., Tzatsos, A., Kampranis, S.C., Serebrennikova, O.B., Bear, S.E. and Tsichlis, P.N. (2008) Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. P Natl Acad Sci USA, 105, 1907-1912. | ||||||||||||||||||||||||||||||
Figure Gallery
About Chromatin Regulator
Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.