Chromatin Regulator | Alias |
| SMARCC1 | Rsc8; SRG3; SWI3; BAF155; CRACC1 |
External Links: | Wiki GeneCards NCBI UniProt |
Related histone modifications: | NA
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Introduction | |
| Full name: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 1
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SMARCC1 is one subunit of the SWI/SNF complex, which acts as a chromatin organizational modifier to regulate gene expression, playing an essential role in early development, differentiation, and tumor suppression (1-7).
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Function and Interaction | |
| SMARCC1 modulates apoptosis caused by glucocorticoids, and it may therefore participate in the development of thymic T cells (8). BAF155 is a subunit of both the SWI/SNF complex and the related EKLF coactivator-remodeling complex 1 (E-RC1), which assists Erythroid KrŸppel-like factor (EKLF) in modulating human beta-globin expression (9). BAF155 is thought to be closely related to cancers (1-5) and was recently shown to be involved in a new tumor-suppressing mechanism through p53 and p21 (10). SMARCC1 (BAF155) interacts with mSin3A in vitro, which is related to regulating gene expression (11). It has also been shown to interact with the other subunits of the SWI/SNF complex to maintain the stability of the whole complex (12).
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Disease Association | |
| SMARCC1 is greatly upregulated in cells following MEN1 (autosomal dominant disorder multiple endocrine neoplasia type 1) transfection. Therefore, this factor could play an important role during the MEN1 pathology process (1). Studies have also shown that colorectal cancer patients with higher SMARCC1 levels may survive longer than those with lower levels (2). SMARCC1 is upregulated in some prostate cancers and is involved in tumor dedifferentiation and recurrence. Thus, SMARCC1 may be used to predict cancer and is a potential a targeting marker during the treatment of prostate cancer and cervical intraepithelial neoplasias (3-5).
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ChIP-Seq data
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References | |
1. Lopez-Egido, J.R., Wang, Y., Gronberg, M., Grimfjard, P., Wang, S., Stalberg, P. and Skogseid, B. (2009) Differentially Regulated Genes in MEN1-transfected BON Cells Using RT-differential Display and Oligonucleotide Microarrays. Anticancer Res, 29, 1859-1866.
2. Andersen, C.L., Christensen, L.L., Thorsen, K., Schepeler, T., Sorensen, F.B., Verspaget, H.W., Simon, R., Kruhoffer, M., Aaltonen, L.A., Laurberg, S. et al. (2009) Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Brit J Cancer, 100, 511-523.
3. Heeboll, S., Borre, M., Ottosen, P.D., Andersen, C.L., Mansilla, F., Dyrskjot, L., Orntoft, T.F. and Torring, N. (2008) SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation. Histol Histopathol, 23, 1069-1076.
4. Hansen, R.L., Heeboll, S., Ottosen, P.D., Dyrskjot, L. and Borre, M. (2011) Smarcc1 expression: A significant predictor of disease-specific survival in patients with clinically localized prostate cancer treated with no intention to cure. Scand J Urol Nephrol, 45, 91-96.
5. Shadeo, A., Chari, R., Lonergan, K.M., Pusic, A., Miller, D., Ehlen, T., Van Niekerk, D., Matisic, J., Richards-Kortum, R., Follen, M. et al. (2008) Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia. Bmc Genomics, 9.
6. Kim, J.K., Huh, S.O., Choi, H., Lee, K.S., Shin, D., Lee, C., Nam, J.S., Kim, H., Chung, H., Lee, H.W. et al. (2001) Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development. Mol Cell Biol, 21, 7787-7795.
7. Schaniel, C., Ang, Y.S., Ratnakumar, K., Cormier, C., James, T., Bernstein, E., Lemischka, I.R. and Paddison, P.J. (2009) Smarcc1/Baf155 Couples Self-Renewal Gene Repression with Changes in Chromatin Structure in Mouse Embryonic Stem Cells. Stem Cells, 27, 2979-2991.
8. Jeon, S.H., Kang, M.G., Kim, Y.H., Jin, Y.H., Lee, C.J., Chung, H.Y., Kwon, H., Park, S.D. and Seong, R.H. (1997) A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. J Exp Med, 185, 1827-1836.
9. Armstrong, J.A., Bieker, J.J. and Emerson, B.M. (1998) A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell, 95, 93-104.
10. Ahn, J., Ko, M., Lee, C., Kim, J., Yoon, H. and Seong, R.H. (2011) Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21(WAF1/CIP1) expression. Oncogene, 30, 445-456.
11. Sif, S., Saurin, A.J., Imbalzano, A.N. and Kingston, R.E. (2001) Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Gene Dev, 15, 603-618.
12. Sohn, D.H., Lee, K.Y., Lee, C., Oh, J., Chung, H., Jeon, S.H. and Seong, R.H. (2007) SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation. J Biol Chem, 282, 10614-10624.
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