Chromatin Regulator | Alias | |||||||||||||||||||
| CHD2 | NA | |||||||||||||||||||
External Links: | Wiki GeneCards NCBI UniProt | |||||||||||||||||||
Related histone modifications: | NA | |||||||||||||||||||
Introduction | ||||||||||||||||||||
| Full name: Chromodomain helicase DNA-binding protein 2 . CHD2 is a chromatin remodeler belonging to the CHD1-CHD2 subfamily of the SNF2 family. It shares homology with CHD1, containing two chromodomains in the N-terminal domain, a central helicase-like ATPase motor, and a C-terminal DNA-binding domain that preferentially binds to A/T-rich sequences involved in regulating development, hematopoiesis, and tumor repression (1-4). | ||||||||||||||||||||
Function and Interaction | ||||||||||||||||||||
| CHD2 plays an important role in DNA damage response signaling, and mutations in CHD2 give rise to the accumulation of γH2AX (which is a chromatin-associated DNA damage response mediator) following DNA damage and to deficiencies in repairing DNA damage caused by ionizing and ultraviolet radiation, thus indicating that CHD2 is essential for maintaining genomic stability (1,5). Mutations in CHD2 are reported to affect the development and survival of mice by delaying embryogenesis and increasing perinatal lethality (6). | ||||||||||||||||||||
Disease Association | ||||||||||||||||||||
| CHD2 has been shown to be involved in tumor suppression, and mutation of CHD2 can result in greater susceptibility to the formation of lymphoid tumors (1). Furthermore, CHD2 is a candidate tumor repressor in classical Hodgkin’s lymphoma (cHL) (7). | ||||||||||||||||||||
ChIP-Seq data
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| Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial. | ||||||||||||||||||||
References | ||||||||||||||||||||
| 1. Nagarajan, P., Onami, T.M., Rajagopalan, S., Kania, S., Donnell, R. and Venkatachalam, S. (2009) Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Oncogene, 28, 1053-1062. 2. Eisen, J.A., Sweder, K.S. and Hanawalt, P.C. (1995) Evolution of the Snf2 Family of Proteins - Subfamilies with Distinct Sequences and Functions. Nucleic Acids Res, 23, 2715-2723. 3. Delmas, V., Stokes, D.G. and Perry, R.P. (1993) A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. Proc Natl Acad Sci U S A, 90, 2414-2418. 4. Woodage, T., Basrai, M.A., Baxevanis, A.D., Hieter, P. and Collins, F.S. (1997) Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A, 94, 11472-11477. 5. Rajagopalan, S., Nepa, J. and Venkatachalam, S. (2012) Chromodomain helicase DNA-binding protein 2 affects the repair of X-ray and UV-induced DNA damage. Environ Mol Mutagen, 53, 44-50. 6. Marfella, C.G.A., Ohkawa, Y., Coles, A.H., Garlick, D.S., Jones, S.N. and Imbalzano, A.N. (2007) Mutation of the SNF2 family member Chd2 affects mouse development and survival. (vol 209, pg 162, 2006). J Cell Physiol, 212, 562-562. 7. Feys, T., Poppe, B., De Preter, K., Van Roy, N., Verhasselt, B., De Paepe, P., De Paepe, A. and Speleman, F. (2007) A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines. Haematol-Hematol J, 92, 913-920. | ||||||||||||||||||||
Figure Gallery
About Chromatin Regulator
Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.