CR Name:
Species:    Tissue or Cell: 

Chromatin Regulator

Alias

KMT2BWBP-7;HRX2;MLL2;MLL4;TRX2;WBP7;CXXC10;MLL1B

External Links:

Wiki    GeneCards    NCBI    UniProt

Related histone modifications:

H3K4me2;H3K4me3

Introduction

Full name: Lysine Methyltransferase 2B. KMT2B is a member of MLL(mixed-lineage leukemia),encodes a protein which contains multiple domains including a CXXC zinc finger,three PHD zinc fingers,two FY-rich domains,and a SET domain,is ubiquitously expressed among adult tissues,is required for mono- di- and trimethylated H3K4 especially H3K4 trimethylation at bivalent homeotic,is essential for mouse embryonic development(1-6).

Function and Interaction

KMT2B is a component of Mll/Trx proteins,methylates mono- di- and trimethylation on histone H3K4,plays a central role in beta-globin locus transcription regulation by being recruited by NFE2,plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development(2,4,6,7).KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter(8).KMT2B mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation(9).

Disease Association

NA

ChIP-Seq data


SpeciesCell lineCell typeTissueDataDownloadSend to CistromeAnalysis FiguresComparisonReference
Mus musculusNonePreadipocyteAdiposeGSE50455 ,GSM1219525
Click  DownloadClick24368734

ChIP-Seq data of related histone modifications


Products/SubstratesSpeciesCell lineCell typeTissueDataDownload Send to CistromeAnalysis FiguresReference
H3K4me3 Mus musculus 3T3-L1 Preadipocyte Adipose GSE41457 ,GSM1017630 Bed     Big wiggle
Click   Download23178591
H3K4me2 Mus musculus None Preadipocyte Adipose GSE50466 ,GSM1218873 Bed     Big wiggle
Click   Download24368734
H3K4me2 Homo sapiens HCT-116 Epithelium Colon GSE51176 ,GSM1240113 Bed     Big wiggle
Click   Download24081332
H3K4me2 Homo sapiens HCT-116 Epithelium Colon GSE51176 ,GSM1240114 Bed     Big wiggle
Click   Download24081332
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE52071 ,GSM1258237 Bed     Big wiggle
Click   Download24423662
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE52071 ,GSM1276705 Bed     Big wiggle
Click   Download24423662
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE60378 ,GSM1482825 Bed     Big wiggle
Click   Download26004229
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE63649 ,GSM1489710 Bed     Big wiggle
Click   Download25745175
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE63491 ,GSM1550780 Bed     Big wiggle
Click   DownloadNA
H3K4me3 Mus musculus KH2 Embryonic Stem Cell Embryo GSE56312 ,GSM1842758 Bed     Big wiggle
Click   Download26235340
H3K4me3 Mus musculus KH2 Embryonic Stem Cell Embryo GSE56312 ,GSM1842759 Bed     Big wiggle
Click   Download26235340
H3K4me3 Mus musculus KH2 Embryonic Stem Cell Embryo GSE56312 ,GSM1842760 Bed     Big wiggle
Click   Download26235340
H3K4me3 Homo sapiens HCT-116 Epithelium Colon GSE72622 ,GSM1866699 Bed     Big wiggle
Click   Download26981421
H3K4me3 Mus musculus 3T3-L1 Preadipocyte Adipose GSE73434 ,GSM1893623 Bed     Big wiggle
Click   Download26590716
H3K4me3 Mus musculus 3T3-L1 Preadipocyte Adipose GSE73434 ,GSM1893633 Bed     Big wiggle
Click   Download26590716
H3K4me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE26136 ,GSM651193 Bed     Big wiggle
Click   Download21335234
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881353 Bed     Big wiggle
Click   Download22682255
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881361 Bed     Big wiggle
Click   Download22682255
H3K4me2 Mus musculus E14 Embryonic Stem Cell Embryo GSE38596 ,GSM881370 Bed     Big wiggle
Click   Download22682255

Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial.

References

1.FitzGerald, K.T., and Diaz, M.O. (1999). MLL2: A new mammalian member of the trx/MLL family of genes. Genomics 59, 187-192.
2.Glaser, S., Lubitz, S., Loveland, K.L., Ohbo, K., Robb, L., Schwenk, F., Seibler, J., Roellig, D., Kranz, A., Anastassiadis, K., et al. (2009). The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin 2, 5.
3.Glaser, S., Schaft, J., Lubitz, S., Vintersten, K., van der Hoeven, F., Tufteland, K.R., Aasland, R., Anastassiadis, K., Ang, S.L., and Stewart, A.F. (2006). Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development 133, 1423-1432.
4.Hu, D., Garruss, A.S., Gao, X., Morgan, M.A., Cook, M., Smith, E.R., and Shilatifard, A. (2013). The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat Struct Mol Biol 20, 1093-1097.
5.Yu, B.D., Hess, J.L., Horning, S.E., Brown, G.A., and Korsmeyer, S.J. (1995). Altered Hox expression and segmental identity in Mll-mutant mice. Nature 378, 505-508.
6.Cho, Y.W., Hong, T., Hong, S., Guo, H., Yu, H., Kim, D., Guszczynski, T., Dressler, G.R., Copeland, T.D., Kalkum, M., et al. (2007). PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282, 20395-20406.
7.Demers, C., Chaturvedi, C.P., Ranish, J.A., Juban, G., Lai, P., Morle, F., Aebersold, R., Dilworth, F.J., Groudine, M., and Brand, M. (2007). Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell 27, 573-584.
8.Ladopoulos, V., Hofemeister, H., Hoogenkamp, M., Riggs, A.D., Stewart, A.F., and Bonifer, C. (2013). The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter. Mol Cell Biol 33, 1383-1393.
9.Kerimoglu, C., Agis-Balboa, R.C., Kranz, A., Stilling, R., Bahari-Javan, S., Benito-Garagorri, E., Halder, R., Burkhardt, S., Stewart, A.F., and Fischer, A. (2013). Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. J Neurosci 33, 3452-3464.

Figure Gallery

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About Chromatin Regulator

Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.

Contact

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