CR Name:
Species:    Tissue or Cell: 

Chromatin Regulator

Alias

EZH2ENX1; EZH1; KMT6; WVS2; ENX-1; KMT6A; MGC9169

External Links:

Wiki    GeneCards    NCBI    UniProt

Related histone modifications:

H3K27me3;H1K25me1;H3K27me1;H3K27me2;H1K26me1

Introduction

Full Name: Enhancer of zeste homolog 2 . Ezh2 is a member of polycomb repressive complex 2 (PRC2). This protein act as a lysine methyltransferase that catalyzes the mono-, di-, and trimethylation of H3K27 and regulates gene expression by engaging in methylation activity, in addition to maintaining pluripotency during ESC differentiation (1-4).

Function and Interaction

Ezh2 is a SET domain-containing lysine methyltransferase capable of catalyzing the mono-, di-, and trimethylation of H3K27, and the majority of these marks are associated with transcriptional repression (1-2). Ezh2 is regarded as an important modulator of cell differentiation. However, recent studies have shown that Ezh2 also participates in the tissue regeneration process. Ezh2 is essential for tissue repair, and deletion of Ezh2 can lead to an inability to engage in pancreatic regeneration and the promotion of KRas (G12D)-induced neoplasia (5). EZH2 is highly expressed in pro-B cells and is involved in early B-cell differentiation, but its expression declines progressively in pre-B cells and immature B cells (6). Ezh2 is thought to be related to DNA methyltransferases and histone deacetylases, indicating that these three types of epigenetic silencing machinery could all contribute to the abnormal control of gene expression in cancer cells (7-9). Ezh2 has also been shown to interact with ATRX, EED, and VAV1 (10-12).

Disease Association

Ezh2 is associated with head and neck squamous cell cancers (HNSCC), myeloid malignancies, prostate cancer, and breast cancer (13-18). Mutations in EZH2 can also result in Weaver syndrome (19-20).

ChIP-Seq data


SpeciesCell lineCell typeTissueDataDownloadSend to CistromeAnalysis FiguresComparisonReference
Homo sapiensSF7761NeuronNAGSE61586 ,GSM1508944
Click  DownloadClick23603901

ChIP-Seq data of related histone modifications


Products/SubstratesSpeciesCell lineCell typeTissueDataDownload Send to CistromeAnalysis FiguresReference
H3K27me3 Mus musculus NA Embryonic Stem Cell Embryo GSE38164 ,GSM1001323 Bed     Big wiggle
Click   Download23352811
H3K27me3 Mus musculus NA Embryonic Stem Cell Embryo GSE38164 ,GSM1001325 Bed     Big wiggle
Click   Download23352811
H3K27me3 Mus musculus NA Embryonic Stem Cell Embryo GSE38164 ,GSM1001327 Bed     Big wiggle
Click   Download23352811
H3K27me3 Homo sapiens NA Myoblast Skeletal Muscle GSE29611 ,GSM1003503 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens DND-41 T Lymphocyte Blood GSE29611 ,GSM1003521 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens NA Epithelium Mammary Gland GSE40867 ,GSM1003736 Bed     Big wiggle
Click   Download24242068
H3K27me3 Homo sapiens Pfeiffer B Lymphocyte Lymph Node GSE40972 ,GSM1006149 Bed     Big wiggle
Click   Download23051747
H3K27me3 Homo sapiens WSU-DLCL2 B Lymphocyte Lymph Node GSE40972 ,GSM1006153 Bed     Big wiggle
Click   Download23051747
H3K27me3 Homo sapiens H1 Embryonic Stem Cell Embryo GSE41111 ,GSM1008647 Bed     Big wiggle
Click   DownloadNA
H3K27me3 Homo sapiens R1 Embryonic Stem Cell Embryo GSE42147 ,GSM1033564 Bed     Big wiggle
Click   Download23171294
H3K27me3 Homo sapiens R1 Embryonic Stem Cell Embryo GSE42147 ,GSM1033567 Bed     Big wiggle
Click   Download23171294
H3K27me3 Mus musculus NA Embryonic Fibroblast Embryo GSE42478 ,GSM1040724 Bed     Big wiggle
Click   Download23260147
H3K27me3 Mus musculus NA Embryonic Fibroblast Embryo GSE44393 ,GSM1084280 Bed     Big wiggle
Click   Download23531360
H3K27me3 Mus musculus NA Embryonic Fibroblast Embryo GSE44393 ,GSM1084281 Bed     Big wiggle
Click   Download23531360
H3K27me3 Mus musculus C2C12 Myoblast Muscle GSE45875 ,GSM1117988 Bed     Big wiggle
Click   Download23942234
H3K27me3 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE47485 ,GSM1151029 Bed     Big wiggle
Click   Download23955559
H3K27me3 Mus musculus NA Fibroblast NA GSE48007 ,GSM1164902 Bed     Big wiggle
Click   Download24075995
H3K27me3 Mus musculus NA Fibroblast NA GSE48007 ,GSM1164903 Bed     Big wiggle
Click   Download24075995
H3K27me3 Homo sapiens R1 Embryonic Stem Cell Embryo GSE48518 ,GSM1180145 Bed     Big wiggle
Click   Download24374312
H3K27me3 Homo sapiens NA iPSC NA GSE48518 ,GSM1180155 Bed     Big wiggle
Click   Download24374312
H3K27me3 Homo sapiens GM12878 Lymphoblastoid Blood GSE50893 ,GSM1233897 Bed     Big wiggle
Click   Download24136358
H3K27me3 Homo sapiens GM12878 Lymphoblastoid Blood GSE50893 ,GSM1233898 Bed     Big wiggle
Click   Download24136358
H3K27me3 Homo sapiens GM12878 Lymphoblastoid Blood GSE50893 ,GSM1233899 Bed     Big wiggle
Click   Download24136358
H3K27me3 Homo sapiens MM1.S B Lymphocyte Blood GSE43743 ,GSM1252088 Bed     Big wiggle
Click   Download24336317
H3K27me3 Homo sapiens iPS C1 iPSC NA GSE52824 ,GSM1272751 Bed     Big wiggle
Click   Download24172903
H3K27me3 Homo sapiens NA Epithelium Mammary Gland GSE53026 ,GSM1280518 Bed     Big wiggle
Click   Download24367927
H3K27me3 Homo sapiens NA Epithelium Mammary Gland GSE53026 ,GSM1280521 Bed     Big wiggle
Click   Download24367927
H3K27me3 Homo sapiens T47D-MTVL Epithelium Mammary Gland GSE53463 ,GSM1294050 Bed     Big wiggle
Click   Download25274727
H3K27me3 Homo sapiens T47D-MTVL Epithelium Mammary Gland GSE53463 ,GSM1294051 Bed     Big wiggle
Click   Download25274727
H3K27me3 Mus musculus None T Lymphocyte None GSE54191 ,GSM1309523 Bed     Big wiggle
Click   Download24584090
H3K27me3 Mus musculus NA Fibroblast NA GSE56981 ,GSM1372587 Bed     Big wiggle
Click   Download25417162
H3K27me3 Homo sapiens MCF-7 Epithelium Mammary Gland GSE57498 ,GSM1383860 Bed     Big wiggle
Click   Download24916973
H3K27me3 Homo sapiens NTKO NA Blood GSE57977 ,GSM1399014 Bed     Big wiggle
Click   Download25188243
H3K27me3 Homo sapiens TKO NA Blood GSE57977 ,GSM1399018 Bed     Big wiggle
Click   Download25188243
H3K27me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE58023 ,GSM1399500 Bed     Big wiggle
Click   Download24999238
H3K27me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE58023 ,GSM1399503 Bed     Big wiggle
Click   Download24999238
H3K27me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE58023 ,GSM1399504 Bed     Big wiggle
Click   Download24999238
H3K27me3 Mus musculus E14 Embryonic Stem Cell Embryo GSE58023 ,GSM1399505 Bed     Big wiggle
Click   Download24999238
H3K27me3 Mus musculus None T Lymphocyte None GSE58775 ,GSM1419280 Bed     Big wiggle
Click   Download25531312
H3K27me3 Mus musculus None T Lymphocyte None GSE58775 ,GSM1419281 Bed     Big wiggle
Click   Download25531312
H3K27me3 Homo sapiens None Proerythroblast Fetal Liver GSE59090 ,GSM1427064 Bed     Big wiggle
Click   Download25578878
H3K27me3 Mus musculus None Embryonic Stem Cell None GSE58414 ,GSM1437465 Bed     Big wiggle
Click   Download26299972
H3K27me3 Mus musculus None Neuron Neuric GSE60240 ,GSM1468398 Bed     Big wiggle
Click   Download25722416
H3K27me3 Mus musculus None Neuron Neuric GSE60240 ,GSM1468399 Bed     Big wiggle
Click   Download25722416
H3K27me3 Mus musculus None Neuron Neuric GSE60240 ,GSM1468400 Bed     Big wiggle
Click   Download25722416
H3K27me3 Homo sapiens NA Neural Stem Cell NA GSE61586 ,GSM1508942 Bed     Big wiggle
Click   Download23603901
H3K27me3 Homo sapiens SF7761 Neuron NA GSE61586 ,GSM1508947 Bed     Big wiggle
Click   Download23603901
H3K27me3 Homo sapiens None Neural Stem Cell None GSE61794 ,GSM1513914 Bed     Big wiggle
Click   DownloadNA
H3K27me3 Homo sapiens LNCaP Epithelium Prostate GSE62492 ,GSM1527833 Bed     Big wiggle
Click   Download25537508
H3K27me3 Mus musculus None None Mammary Gland GSE70440 ,GSM1754891 Bed     Big wiggle
Click   Download26250110
H3K27me3 Mus musculus None None Mammary Gland GSE70440 ,GSM1754897 Bed     Big wiggle
Click   Download26250110
H3K27me3 Mus musculus None None Mammary Gland GSE70440 ,GSM1754904 Bed     Big wiggle
Click   Download26250110
H3K27me3 Homo sapiens Pfeiffer B Lymphocyte Lymph Node GSE74359 ,GSM1918726 Bed     Big wiggle
Click   Download26687680
H3K27me3 Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM466734 Bed     Big wiggle
Click   Download19829295
H3K27me3 Homo sapiens iPS-18c iPSC NA GSE19465 ,GSM537674 Bed     Big wiggle
Click   Download20944595
H3K27me3 Homo sapiens iPS-20b iPSC NA GSE19465 ,GSM537700 Bed     Big wiggle
Click   Download20944595
H3K27me3 Homo sapiens iPS A1 iPSC NA GSE23455 ,GSM575301 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens iPS C1 iPSC NA GSE23455 ,GSM575303 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens iPS 4 iPSC NA GSE23455 ,GSM575304 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens PDB1lox-17/puro-5 iPSC NA GSE23455 ,GSM575306 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens PDB2lox-17 iPSC NA GSE23455 ,GSM575307 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens PDB1lox-21/puro-26 iPSC NA GSE23455 ,GSM575308 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens PDB2lox-21 iPSC NA GSE23455 ,GSM575309 Bed     Big wiggle
Click   Download20682450
H3K27me3 Homo sapiens MCF-7 Epithelium Mammary Gland GSE23701 ,GSM588564 Bed     Big wiggle
Click   Download21179027
H3K27me3 Homo sapiens MCF-7 Epithelium Mammary Gland GSE23701 ,GSM588565 Bed     Big wiggle
Click   Download21179027
H3K27me3 Mus musculus TNGA Embryonic Stem Cell Embryo GSE23943 ,GSM590114 Bed     Big wiggle
Click   Download22541430
H3K27me3 Homo sapiens K562 Erythroblast Bone Marrow GSE24685 ,GSM608166 Bed     Big wiggle
Click   Download21126370
H3K27me3 Homo sapiens K562 Erythroblast Bone Marrow GSE24685 ,GSM608167 Bed     Big wiggle
Click   Download21126370
H3K27me3 Homo sapiens K562 Erythroblast Bone Marrow GSE24779 ,GSM610338 Bed     Big wiggle
Click   Download20959602
H3K27me3 Homo sapiens iPS-20b iPSC NA GSE19465 ,GSM621416 Bed     Big wiggle
Click   Download20944595
H3K27me3 Homo sapiens iPS-15b iPSC NA GSE19465 ,GSM621433 Bed     Big wiggle
Click   Download20944595
H3K27me3 Homo sapiens NA Endothelial Cell Umbilical Vein GSE26320 ,GSM646416 Bed     Big wiggle
Click   Download21441907
H3K27me3 Homo sapiens NHEK Keratinocyte Skin GSE26320 ,GSM646458 Bed     Big wiggle
Click   Download21441907
H3K27me3 Homo sapiens NHEK Keratinocyte Skin GSE26320 ,GSM646459 Bed     Big wiggle
Click   Download21441907
H3K27me3 Homo sapiens NHLF Fibroblast Lung GSE26320 ,GSM646479 Bed     Big wiggle
Click   Download21441907
H3K27me3 Homo sapiens iPS DF 6.9 iPSC NA GSE16256 ,GSM706068 Bed     Big wiggle
Click   Download19829295
H3K27me3 Mus musculus C2C12 Myoblast Muscle GSE25308 ,GSM721294 Bed     Big wiggle
Click   Download21551099
H3K27me3 Homo sapiens NA Endothelial Cell Umbilical Vein GSE29611 ,GSM733688 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens HeLa-S3 Epithelium Cervix GSE29611 ,GSM733696 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens NA Astrocyte Brain GSE29611 ,GSM733729 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens NHDF-Ad Fibroblast Skin GSE29611 ,GSM733745 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens H1 Embryonic Stem Cell Embryo GSE29611 ,GSM733748 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens HepG2 Epithelium Liver GSE29611 ,GSM733754 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens NHLF Fibroblast Lung GSE29611 ,GSM733764 Bed     Big wiggle
Click   Download22955616
H3K27me3 Homo sapiens iPS DF 6.9 iPSC NA GSE16256 ,GSM752971 Bed     Big wiggle
Click   Download19829295
H3K27me3 Homo sapiens NA iPSC NA GSE17312 ,GSM772847 Bed     Big wiggle
Click   Download20944595
H3K27me3 Homo sapiens NA iPSC NA GSE17312 ,GSM772935 Bed     Big wiggle
Click   Download20944595
H3K27me3 Mus musculus C2C12 Myoblast Muscle GSE33024 ,GSM818948 Bed     Big wiggle
Click   Download22085726
H3K27me3 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE28254 ,GSM821394 Bed     Big wiggle
Click   Download22466170
H3K27me3 Mus musculus CMTi-1 Embryonic Stem Cell Embryo GSE34483 ,GSM849942 Bed     Big wiggle
Click   Download23260488
H3K27me3 Homo sapiens HEK293T Epithelium Embryonic Kidney GSE34774 ,GSM855015 Bed     Big wiggle
Click   Download22325352
H3K27me3 Mus musculus R1 Embryonic Stem Cell Embryo GSE36294 ,GSM886505 Bed     Big wiggle
Click   Download24381111
H3K27me3 Mus musculus NA Embryonic Stem Cell NA GSE36905 ,GSM905438 Bed     Big wiggle
Click   Download22948768
H3K27me3 Mus musculus NA Embryonic Stem Cell NA GSE36905 ,GSM905446 Bed     Big wiggle
Click   Download22948768
H3K27me3 Homo sapiens None Proerythroblast Fetal Liver GSE36985 ,GSM908042 Bed     Big wiggle
Click   Download23041383
H3K27me3 Homo sapiens NA Endothelial Cell Umbilical Vein GSE35583 ,GSM945180 Bed     Big wiggle
Click   Download22955617
H3K27me3 Homo sapiens GM06990 B Lymphocyte Blood GSE35583 ,GSM945205 Bed     Big wiggle
Click   Download22955617
H3K27me3 Homo sapiens NHEK Keratinocyte Skin GSE35583 ,GSM945300 Bed     Big wiggle
Click   Download22955617
H3K27me1 Homo sapiens MCF-7 Epithelium Mammary Gland GSE38447 ,GSM946851 Bed     Big wiggle
Click   Download22951069
H3K27me3 Homo sapiens LNCaP Epithelium Prostate GSE38683 ,GSM947526 Bed     Big wiggle
Click   Download23245995
H3K27me3 Homo sapiens M23F iPSC NA GSE39137 ,GSM956688 Bed     Big wiggle
Click   DownloadNA
H3K27me3 Homo sapiens LNCaP-Abl Epithelium Prostate GSE39459 ,GSM969563 Bed     Big wiggle
Click   Download23239736
H3K27me3 Homo sapiens LNCaP Epithelium Prostate GSE39459 ,GSM969571 Bed     Big wiggle
Click   Download23239736
H3K27me1 Mus musculus E36 Embryonic Stem Cell Embryo GSE39496 ,GSM970223 Bed     Big wiggle
Click   Download24289921
H3K27me3 Mus musculus V6.5 Embryonic Stem Cell Embryo GSE40065 ,GSM984546 Bed     Big wiggle
Click   Download23990805

Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial.

References

1. Muller, J., Hart, C.M., Francis, N.J., Vargas, M.L., Sengupta, A., Wild, B., Miller, E.L., O'Connor, M.B., Kingston, R.E. and Simon, J.A. (2002) Histone methyltransferase activity of a Drosophila polycomb group repressor complex. Cell, 111, 197-208.
2. Cao, R., Wang, L.J., Wang, H.B., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R.S. and Zhang, Y. (2002) Role of histone H3 lysine 27 methylation in polycomb-group silencing. Science, 298, 1039-1043.
3. Shen, X.H., Liu, Y.C., Hsu, Y.J., Fujiwara, Y., Kim, J., Mao, X.H., Yuan, G.C. and Orkin, S.H. (2008) EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency. Mol Cell, 32, 491-502.
4. Margueron, R., Li, G.H., Sarma, K., Blais, A., Zavadil, J., Woodcock, C.L., Dyniacht, B.D. and Reinberg, D. (2008) Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms. Mol Cell, 32, 503-518.
5. Mallen-St Clair, J., Soydaner-Azeloglu, R., Lee, K.E., Taylor, L., Livanos, A., Pylayeva-Gupta, Y., Miller, G., Margueron, R., Reinberg, D. and Bar-Sagi, D. (2012) EZH2 couples pancreatic regeneration to neoplastic progression. Gene Dev, 26, 439-444.
6. Su, I.H., Basavaraj, A., Krutchinsky, A.N., Hobert, O., Ullrich, A., Chait, B.T. and Tarakhovsky, A. (2003) Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol, 4, 124-131.
7. Vire, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.M. et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature, 439, 871-874.
8. Tie, F., Furuyama, T., Prasad-Sinha, J., Jane, E. and Harte, P.J. (2001) The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development, 128, 275-286.
9. Simon, J.A. and Lange, C.A. (2008) Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res-Fund Mol M, 647, 21-29.
10. Cardoso, C., Timsit, S., Villard, L., Khrestchatisky, M., Fontes, M. and Colleaux, L. (1998) Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet, 7, 679-684.
11. van Lohuizen, M., Tijms, M., Voncken, J.W., Schumacher, A., Magnuson, T. and Wientjens, E. (1998) Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: Indication for separate Pc-G complexes. Mol Cell Biol, 18, 3572-3579.
12. Hobert, O., Jallal, B. and Ullrich, A. (1996) Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol, 16, 3066-3073.
13. Fathi, A.T. and Abdel-Wahab, O. (2012) Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy. Adv Hematol, 2012, 469592.
14. Stransky, N., Egloff, A.M., Tward, A.D., Kostic, A.D., Cibulskis, K., Sivachenko, A., Kryukov, G.V., Lawrence, M.S., Sougnez, C., McKenna, A. et al. (2011) The mutational landscape of head and neck squamous cell carcinoma. Science, 333, 1157-1160.
15. Varambally, S., Dhanasekaran, S.M., Zhou, M., Barrette, T.R., Kumar-Sinha, C., Sanda, M.G., Ghosh, D., Pienta, K.J., Sewalt, R.G.A.B., Otte, A.P. et al. (2002) The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature, 419, 624-629.
16. Saramaki, O.R., Tammela, T.L.J., Martikainen, P.M., Vessella, R.L. and Visakorpi, T. (2006) The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer. Gene Chromosome Canc, 45, 639-645.
17. Collett, K., Eide, G.E., Arnes, J., Stefansson, I.M., Eide, J., Braaten, A., Aas, T., Otte, A.P. and Akslen, L.A. (2006) Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res, 12, 1168-1174.
18. Kleer, C.G., Cao, Q., Varambally, S., Shen, R.L., Ota, L., Tomlins, S.A., Ghosh, D., Sewalt, R.G.A.B., Otte, A.P., Hayes, D.F. et al. (2003) EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. P Natl Acad Sci USA, 100, 11606-11611.
19. Tatton-Brown, K., Hanks, S., Ruark, E., Zachariou, A., Duarte, S.D., Ramsay, E., Snape, K., Murray, A., Perdeaux, E.R., Seal, S. et al. (2011) Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height. Oncotarget, 2, 1127-1133.
20. Gibson, W.T., Hood, R.L., Zhan, S.H., Bulman, D.E., Fejes, A.P., Moore, R., Mungall, A.J., Eydoux, P., Babul-Hirji, R., An, J.H. et al. (2012) Mutations in EZH2 Cause Weaver Syndrome. Am J Hum Genet, 90, 110-118.

Figure Gallery

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About Chromatin Regulator

Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.

Contact

houshuang [at] tongji dot edu dot cn