CR Name:
Species:    Tissue or Cell: 

Chromatin Regulator

Alias

EP300p300; KAT3B; RSTS2

External Links:

Wiki    GeneCards    NCBI    UniProt

Related histone modifications:

H3K27ac;H3K18ac;H4K16ac;H4K12ac;H4K8ac;H4K5ac;H3K56ac

Introduction

Full Name: E1A binding protein p300 . Ep300 was first identified as one of the many targets of the adenovirus E1A protein. Ep300 acts as both a histone acetyltransferase and a coactivator in some signal-associated events. It possesses three cysteine-histidine-rich domains (CH1, CH2, and CH3), a KIX domain, a bromodomain, a histone acetyltransferase (HAT) domain and a C-terminal glutamine-rich domain. It is closely related to CREBBP and exhibits some redundant functions associated with the activities of hundreds of transcription factors, cell proliferation, differentiation, and development (1-6).

Function and Interaction

Ep300 has been shown to play a role in organ development in mice, including neural, vertebral, limb, heart, skin, and hair development, and its expression is thought to be developmentally modulated in a stage- and tissue-specific manner during mouse embryogenesis. Although Ep300 and CREBBP share many common functions, their expression patterns exhibit subtle differences at the cellular and subcellular levels during embryogenesis (4). Cells lacking Ep300 exhibit defects in neurulation, proliferation, and heart development (5). The functions of Ep300 and CREBBP in F9 cell differentiation also differ (6). Signal transducer and activator of transcription 2 (STAT2) and the RelA (p65) subunit of NF-kappaB compete for binding with the first zinc finger domain of p300, thus enabling interferon-alpha (IFN-alpha) to suppress NF-kappaB-dependent HIV gene expression induced by tumor necrosis factor-alpha (TNF-alpha) (7). Ep300 is believed to be recruited by ligand-activated ER, resulting in the acetylation of ACTR, thereby destabilizing the ACTR-p300-ER complex and downregulating nuclear receptor-related transcription (8). Ep300 acetylates p53 in its C-terminal DNA-binding regulatory domain and exhibits other non-histone substrates, such as TFIIE (ocmponents of the general transcription machinery) (9-10). Ep300 acetylates promoter histones through its HAT domain, thus regulating transcription, and the bromodomain of Ep300 could modulate its acetyltransferase activity. Additionally, Ep300 can interact with transcription factors, thus regulating the expression of target genes transcribed by RNA polymerases I, II, and III (11-14). Ep300 is associated with CREB and other factors through its KIX domain, which controls CREB-related specific gene transcription (15). E1A is an adenoviral oncoprotein that binds to p300/CBP and is involved in regulating transforming growth factor (TGF)-beta signaling (16).

Disease Association

Mutations in p300 can cause Rubinstein-Taybi syndrome, which is characterized by facial abnormalities, broad thumbs, large toes, and mental retardation (17).

ChIP-Seq data


SpeciesCell lineCell typeTissueDataDownloadSend to CistromeAnalysis FiguresComparisonReference
Mus musculus3T3-L1PreadipocyteAdiposeGSE56872 ,GSM1370467
Click  DownloadClick24857652

ChIP-Seq data of related histone modifications


Products/SubstratesSpeciesCell lineCell typeTissueDataDownload Send to CistromeAnalysis FiguresReference
H3K27ac Mus musculus None None Brain GSE49847 ,GSM1000094 Bed     Big wiggle
Click   Download25409824
H3K27ac Mus musculus None Cortex None GSE49847 ,GSM1000100 Bed     Big wiggle
Click   Download25409824
H3K27ac Mus musculus CH12 Lymphoblastoid Blood GSE49847 ,GSM1000117 Bed     Big wiggle
Click   Download25409824
H3K27ac Mus musculus MEL Erythroid Progenitor Cell Blood GSE49847 ,GSM1000142 Bed     Big wiggle
Click   Download25409824
H3K27ac Homo sapiens A549 Epithelium Lung GSE29611 ,GSM1003578 Bed     Big wiggle
Click   Download22955616
H3K27ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE41009 ,GSM1006721 Bed     Big wiggle
Click   Download23382218
H3K27ac Homo sapiens A549 Epithelium Lung GSE42375 ,GSM1038443 Bed     Big wiggle
Click   Download24004852
H3K27ac Homo sapiens A549 Epithelium Lung GSE42375 ,GSM1038444 Bed     Big wiggle
Click   Download24004852
H4K8ac Homo sapiens A549 Epithelium Lung GSE42375 ,GSM1038469 Bed     Big wiggle
Click   Download24004852
H4K8ac Homo sapiens A549 Epithelium Lung GSE42375 ,GSM1038470 Bed     Big wiggle
Click   Download24004852
H3K27ac Homo sapiens OCI-Ly1 B Lymphocyte Bone Marrow GSE46663 ,GSM1133646 Bed     Big wiggle
Click   Download24332044
H3K56ac Mus musculus E14 Embryonic Stem Cell Embryo GSE47387 ,GSM1148636 Bed     Big wiggle
Click   Download23798425
H4K16ac Mus musculus 46C Embryonic Stem Cell Embryo GSE47761 ,GSM1156617 Bed     Big wiggle
Click   Download23990607
H4K16ac Mus musculus 46C Embryonic Stem Cell Embryo GSE47761 ,GSM1156618 Bed     Big wiggle
Click   Download23990607
H3K27ac Homo sapiens HCT-116 Epithelium Colon GSE50610 ,GSM1224664 Bed     Big wiggle
Click   DownloadNA
H3K27ac Homo sapiens None Endothelial Cell Umbilical Vein GSE50144 ,GSM1226370 Bed     Big wiggle
Click   Download24721177
H3K27ac Homo sapiens None Endothelial Cell Umbilical Vein GSE50144 ,GSM1226371 Bed     Big wiggle
Click   Download24721177
H3K27ac Homo sapiens GM12878 Lymphoblastoid Blood GSE50893 ,GSM1233889 Bed     Big wiggle
Click   Download24136358
H3K27ac Homo sapiens GM12878 Lymphoblastoid Blood GSE50893 ,GSM1233890 Bed     Big wiggle
Click   Download24136358
H3K27ac Homo sapiens GM12878 Lymphoblastoid Blood GSE50893 ,GSM1233891 Bed     Big wiggle
Click   Download24136358
H3K27ac Mus musculus E14 Embryonic Stem Cell Embryo GSE51006 ,GSM1234533 Bed     Big wiggle
Click   Download24289921
H3K27ac Homo sapiens LNCaP Epithelium Prostate GSE51621 ,GSM1249447 Bed     Big wiggle
Click   Download24497837
H3K27ac Homo sapiens LNCaP Epithelium Prostate GSE51621 ,GSM1249448 Bed     Big wiggle
Click   Download24497837
H3K27ac Homo sapiens HEK293T Epithelium Embryonic Kidney GSE51633 ,GSM1249889 Bed     Big wiggle
Click   Download24360279
H3K27ac Mus musculus None Epithelium Heart GSE52123 ,GSM1260015 Bed     Big wiggle
Click   Download25249388
H3K27ac Mus musculus None T Lymphocyte None GSE54191 ,GSM1309521 Bed     Big wiggle
Click   Download24584090
H3K27ac Mus musculus None Stem cell Ectoderm GSE56138 ,GSM1355171 Bed     Big wiggle
Click   Download24905168
H3K27ac Mus musculus None Stem cell Ectoderm GSE56138 ,GSM1355172 Bed     Big wiggle
Click   Download24905168
H4K16ac Homo sapiens IMR90 Fibroblast Lung GSE56307 ,GSM1358823 Bed     Big wiggle
Click   Download25512559
H4K16ac Homo sapiens IMR90 Fibroblast Lung GSE56307 ,GSM1358824 Bed     Big wiggle
Click   Download25512559
H3K27ac Mus musculus HL-1 Cardiomyocyte Muscle GSE47085 ,GSM1359845 Bed     Big wiggle
Click   Download25564442
H3K27ac Homo sapiens PC-3 Epithelium Prostate GSE57498 ,GSM1383871 Bed     Big wiggle
Click   Download24916973
H3K27ac Mus musculus None Stem cell Ectoderm GSE58408 ,GSM1410356 Bed     Big wiggle
Click   DownloadNA
H3K27ac Mus musculus 3T3-L1 Preadipocyte Adipose GSE58491 ,GSM1412455 Bed     Big wiggle
Click   Download25503565
H3K27ac Mus musculus 3T3-L1 Preadipocyte Adipose GSE58491 ,GSM1412473 Bed     Big wiggle
Click   Download25503565
H3K27ac Mus musculus 3T3-L1 Preadipocyte Adipose GSE58491 ,GSM1412512 Bed     Big wiggle
Click   Download25503565
H3K27ac Homo sapiens IMR90 Fibroblast Lung GSE58740 ,GSM1418963 Bed     Big wiggle
Click   Download25391375
H3K27ac Homo sapiens IMR90 Fibroblast Lung GSE58740 ,GSM1418964 Bed     Big wiggle
Click   Download25391375
H4K16ac Homo sapiens IMR90 Fibroblast Lung GSE58740 ,GSM1418966 Bed     Big wiggle
Click   Download25391375
H3K27ac Homo sapiens IMR90 Fibroblast Lung GSE59693 ,GSM1442703 Bed     Big wiggle
Click   Download25525796
H3K27ac Homo sapiens None Keratinocyte None GSE59827 ,GSM1446921 Bed     Big wiggle
Click   Download26034101
H3K27ac Mus musculus None Pro-B Lymphocyte None GSE60005 ,GSM1463433 Bed     Big wiggle
Click   Download26477271
H3K27ac Mus musculus None Epithelium Heart GSE52123 ,GSM1478327 Bed     Big wiggle
Click   Download25249388
H3K27ac Mus musculus None Epithelium Heart GSE52123 ,GSM1478331 Bed     Big wiggle
Click   Download25249388
H3K27ac Mus musculus None None Brain GSE60411 ,GSM1479204 Bed     Big wiggle
Click   Download25519132
H3K27ac Mus musculus E14 Embryonic Stem Cell Embryo GSE63649 ,GSM1489707 Bed     Big wiggle
Click   Download25745175
H3K27ac Mus musculus E14 Embryonic Stem Cell Embryo GSE63649 ,GSM1489708 Bed     Big wiggle
Click   Download25745175
H3K27ac Mus musculus None Embryonic Stem Cell None GSE61188 ,GSM1499128 Bed     Big wiggle
Click   Download25699711
H3K27ac Mus musculus None Embryonic Stem Cell None GSE61188 ,GSM1499129 Bed     Big wiggle
Click   Download25699711
H3K27ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE62193 ,GSM1521721 Bed     Big wiggle
Click   Download25533951
H3K27ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE62193 ,GSM1521726 Bed     Big wiggle
Click   Download25533951
H3K27ac Mus musculus AtT-20 None None GSE64483 ,GSM1572159 Bed     Big wiggle
Click   Download25605944
H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE64489 ,GSM1572299 Bed     Big wiggle
Click   Download26728555
H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE64489 ,GSM1572300 Bed     Big wiggle
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H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE64489 ,GSM1572301 Bed     Big wiggle
Click   Download26728555
H3K27ac Homo sapiens T47D Epithelium Mammary Gland GSE69107 ,GSM1589474 Bed     Big wiggle
Click   Download26406377
H3K27ac Mus musculus 8946 T Lymphocyte None GSE66147 ,GSM1615136 Bed     Big wiggle
Click   Download26522984
H3K27ac Homo sapiens None Keratinocyte None GSE67382 ,GSM1645724 Bed     Big wiggle
Click   Download26683334
H3K27ac Homo sapiens None Keratinocyte None GSE67382 ,GSM1645725 Bed     Big wiggle
Click   Download26683334
H3K27ac Homo sapiens None B Lymphocyte None GSE69558 ,GSM1703918 Bed     Big wiggle
Click   Download26229090
H3K27ac Homo sapiens TC-797 None None GSE70870 ,GSM1820938 Bed     Big wiggle
Click   Download26220994
H3K27ac Homo sapiens TC-797 None None GSE70870 ,GSM1820939 Bed     Big wiggle
Click   Download26220994
H3K27ac Homo sapiens TC-797 None None GSE70870 ,GSM1820958 Bed     Big wiggle
Click   Download26220994
H3K27ac Mus musculus None Pro-B Lymphocyte None GSE60005 ,GSM1869131 Bed     Big wiggle
Click   Download26477271
H3K27ac Mus musculus None T Lymphocyte None GSE73418 ,GSM1893219 Bed     Big wiggle
Click   Download26510014
H3K27ac Mus musculus R1 Embryonic Stem Cell Embryo GSE74268 ,GSM1915954 Bed     Big wiggle
Click   Download26628093
H3K27ac Mus musculus R1 Embryonic Stem Cell Embryo GSE74268 ,GSM1915956 Bed     Big wiggle
Click   Download26628093
H3K18ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM469965 Bed     Big wiggle
Click   Download19829295
H4K5ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM469975 Bed     Big wiggle
Click   Download19829295
H3K18ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521884 Bed     Big wiggle
Click   Download19829295
H3K56ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521902 Bed     Big wiggle
Click   Download19829295
H3K56ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521903 Bed     Big wiggle
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H4K5ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521918 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521919 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521922 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens IMR90 Fibroblast Lung GSE16256 ,GSM521923 Bed     Big wiggle
Click   Download19829295
H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE24165 ,GSM594578 Bed     Big wiggle
Click   Download21106759
H3K27ac Mus musculus V6.5 Embryonic Stem Cell Embryo GSE24165 ,GSM594579 Bed     Big wiggle
Click   Download21106759
H3K27ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE24447 ,GSM602294 Bed     Big wiggle
Click   Download21160473
H3K27ac Homo sapiens None Neuroectoderm None GSE24447 ,GSM602302 Bed     Big wiggle
Click   Download21160473
H3K56ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM605317 Bed     Big wiggle
Click   Download19829295
H4K5ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM605330 Bed     Big wiggle
Click   Download19829295
H3K27ac Homo sapiens K562 Erythroblast Bone Marrow GSE26320 ,GSM646434 Bed     Big wiggle
Click   Download21441907
H3K56ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM667627 Bed     Big wiggle
Click   Download19829295
H3K56ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE16256 ,GSM667628 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE16256 ,GSM667637 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE16256 ,GSM667638 Bed     Big wiggle
Click   Download19829295
H3K27ac Homo sapiens LNCaP Epithelium Prostate GSE27824 ,GSM686938 Bed     Big wiggle
Click   Download21572438
H4K5ac Homo sapiens LNCaP Epithelium Prostate GSE27824 ,GSM686939 Bed     Big wiggle
Click   Download21572438
H4K5ac Homo sapiens LNCaP Epithelium Prostate GSE27824 ,GSM686940 Bed     Big wiggle
Click   Download21572438
H3K18ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE16256 ,GSM706064 Bed     Big wiggle
Click   Download19829295
H3K56ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE16256 ,GSM706076 Bed     Big wiggle
Click   Download19829295
H3K18ac Mus musculus C2C12 Myoblast Muscle GSE25308 ,GSM721302 Bed     Big wiggle
Click   Download21551099
H3K18ac Mus musculus C2C12 Myoblast Muscle GSE25308 ,GSM721303 Bed     Big wiggle
Click   Download21551099
H4K12ac Mus musculus C2C12 Myoblast Muscle GSE25308 ,GSM721305 Bed     Big wiggle
Click   Download21551099
H3K27ac Homo sapiens K562 Erythroblast Bone Marrow GSE29611 ,GSM733656 Bed     Big wiggle
Click   Download22955616
H3K27ac Homo sapiens HeLa-S3 Epithelium Cervix GSE29611 ,GSM733684 Bed     Big wiggle
Click   Download22955616
H3K27ac Homo sapiens None Osteoblast Bone GSE29611 ,GSM733739 Bed     Big wiggle
Click   Download22955616
H3K56ac Homo sapiens H9 Embryonic Stem Cell Embryo GSE16256 ,GSM752976 Bed     Big wiggle
Click   Download19829295
H4K5ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM752990 Bed     Big wiggle
Click   Download19829295
H3K27ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM753426 Bed     Big wiggle
Click   Download19829295
H3K27ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM767342 Bed     Big wiggle
Click   Download19829295
H3K18ac Homo sapiens IMR90 Fibroblast Lung GSE32340 ,GSM802400 Bed     Big wiggle
Click   Download22499665
H3K56ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM807397 Bed     Big wiggle
Click   Download19829295
H4K5ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM807404 Bed     Big wiggle
Click   Download19829295
H3K18ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM818023 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM818059 Bed     Big wiggle
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H3K27ac Mus musculus None Cortex None GSE29218 ,GSM851272 Bed     Big wiggle
Click   Download22763441
H3K27ac Mus musculus None Epithelium Lung GSE29218 ,GSM851276 Bed     Big wiggle
Click   Download22763441
H3K27ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM864800 Bed     Big wiggle
Click   Download19829295
H3K27ac Homo sapiens OCI-Ly1 B Lymphocyte Bone Marrow GSE29282 ,GSM898058 Bed     Big wiggle
Click   Download23911289
H3K27ac Homo sapiens OCI-Ly1 B Lymphocyte Bone Marrow GSE29282 ,GSM898059 Bed     Big wiggle
Click   Download23911289
H3K18ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM908949 Bed     Big wiggle
Click   Download19829295
H4K12ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM908962 Bed     Big wiggle
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H4K12ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM908963 Bed     Big wiggle
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H4K8ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM908964 Bed     Big wiggle
Click   Download19829295
H4K8ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM908965 Bed     Big wiggle
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H3K27ac Mus musculus C2C12 Myoblast Muscle GSE37525 ,GSM921130 Bed     Big wiggle
Click   Download23249738
H3K27ac Mus musculus C2C12 Myoblast Muscle GSE37525 ,GSM921131 Bed     Big wiggle
Click   Download23249738
H3K27ac Homo sapiens None Endothelial Cell Umbilical Vein GSE38555 ,GSM945520 Bed     Big wiggle
Click   Download24721177
H3K27ac Homo sapiens HCT-116 Epithelium Colon GSE31755 ,GSM945853 Bed     Big wiggle
Click   DownloadNA
H3K18ac Homo sapiens H1 Embryonic Stem Cell Embryo GSE16256 ,GSM956006 Bed     Big wiggle
Click   Download19829295

Notice: For bigwiggle or bed file download, if the browser cannot automatically download the file, users can right click the hyperlink and then click the "Save link as..." button, which will automatically redirect to download dialogue box, or click the "Copy link address" button and access the website in a new tab page. For data analysis in Cistrome, users should first login into the Cistrome website, then press the "Send Bed" or "Send Big wiggle" button. For data download by Cistrome, users can follow this tutorial.

References

1. Eckner, R., Ewen, M.E., Newsome, D., Gerdes, M., DeCaprio, J.A., Lawrence, J.B. and Livingston, D.M. (1994) Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev, 8, 869-884.
2. Giles, R.H., Peters, D.J. and Breuning, M.H. (1998) Conjunction dysfunction: CBP/p300 in human disease. Trends Genet, 14, 178-183.
3. Vo, N. and Goodman, R.H. (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem, 276, 13505-13508.
4. Partanen, A., Motoyama, J. and Hui, C.C. (1999) Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis. Int J Dev Biol, 43, 487-494.
5. Yao, T.P., Oh, S.P., Fuchs, M., Zhou, N.D., Ch'ng, L.E., Newsome, D., Bronson, R.T., Li, E., Livingston, D.M. and Eckner, R. (1998) Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell, 93, 361-372.
6. Ugai, H., Uchida, K., Kawasaki, H. and Yokoyama, K.K. (1999) The coactivators p300 and CBP have different functions during the differentiation of F9 cells. J Mol Med-Jmm, 77, 481-494.
7. Hottiger, M.O., Felzien, L.K. and Nabel, G.J. (1998) Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300. Embo Journal, 17, 3124-3134.
8. Chen, H.W., Lin, R.J., Xie, W., Wilpitz, D. and Evans, R.M. (1999) Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell, 98, 675-686.
9. Gu, W. and Roeder, R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90, 595-606.
10. Imhof, A., Yang, X.J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P. and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr Biol, 7, 689-692.
11. Ito, T., Ikehara, T., Nakagawa, T., Kraus, W.L. and Muramatsu, M. (2000) p300-Mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Gene Dev, 14, 1899-1907.
12. Suganuma, T., Kawabata, M., Ohshima, T. and Ikeda, M.A. (2002) Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator. P Natl Acad Sci USA, 99, 13073-13078.
13. Kim, J.H., Cho, E.J., Kim, S.T. and Youn, H.D. (2005) CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nature Structural & Molecular Biology, 12, 423-428.
14. Ghosh, A.K. and Varga, J. (2007) The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J Cell Physiol, 213, 663-671.
15. Xu, W., Chen, H.W., Du, K.Y., Asahara, H., Tini, M., Emerson, B.M., Montminy, M. and Evans, R.M. (2001) A transcriptional switch mediated by cofactor methylation. Science, 294, 2507-2511.
16. Nishihara, A., Hanai, J., Imamura, T., Miyazono, K. and Kawabata, M. (1999) E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. J Biol Chem, 274, 28716-28723.
17. Roelfsema, J.H., White, S.J., Ariyurek, Y., Bartholdi, D., Niedrist, D., Papadia, F., Bacino, C.A., den Dunnen, J.T., van Ommen, G.J.B., Breuning, M.H. et al. (2005) Genetic heterogeneity in Rubinstein-Taybi syndrome: Mutations in both the CBP and EP300 genes cause disease. Am J Hum Genet, 76, 572-580.

Figure Gallery

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About Chromatin Regulator

Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.

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