CR Name:
Species:    Tissue or Cell: 

Chromatin Regulator

Alias

CHD2NA

External Links:

Wiki    GeneCards    NCBI    UniProt

Related histone modifications:

NA

Introduction

Full name: Chromodomain helicase DNA-binding protein 2 . CHD2 is a chromatin remodeler belonging to the CHD1-CHD2 subfamily of the SNF2 family. It shares homology with CHD1, containing two chromodomains in the N-terminal domain, a central helicase-like ATPase motor, and a C-terminal DNA-binding domain that preferentially binds to A/T-rich sequences involved in regulating development, hematopoiesis, and tumor repression (1-4).

Function and Interaction

CHD2 plays an important role in DNA damage response signaling, and mutations in CHD2 give rise to the accumulation of γH2AX (which is a chromatin-associated DNA damage response mediator) following DNA damage and to deficiencies in repairing DNA damage caused by ionizing and ultraviolet radiation, thus indicating that CHD2 is essential for maintaining genomic stability (1,5). Mutations in CHD2 are reported to affect the development and survival of mice by delaying embryogenesis and increasing perinatal lethality (6).

Disease Association

CHD2 has been shown to be involved in tumor suppression, and mutation of CHD2 can result in greater susceptibility to the formation of lymphoid tumors (1). Furthermore, CHD2 is a candidate tumor repressor in classical Hodgkin’s lymphoma (cHL) (7).

ChIP-Seq data


SpeciesCell lineCell typeTissueDataDownloadSend to CistromeAnalysis FiguresComparisonReference
Homo sapiensK562ErythroblastBone MarrowGSE31477 ,GSM935502
Click  DownloadNA25409831

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References

1. Nagarajan, P., Onami, T.M., Rajagopalan, S., Kania, S., Donnell, R. and Venkatachalam, S. (2009) Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Oncogene, 28, 1053-1062.
2. Eisen, J.A., Sweder, K.S. and Hanawalt, P.C. (1995) Evolution of the Snf2 Family of Proteins - Subfamilies with Distinct Sequences and Functions. Nucleic Acids Res, 23, 2715-2723.
3. Delmas, V., Stokes, D.G. and Perry, R.P. (1993) A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. Proc Natl Acad Sci U S A, 90, 2414-2418.
4. Woodage, T., Basrai, M.A., Baxevanis, A.D., Hieter, P. and Collins, F.S. (1997) Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A, 94, 11472-11477.
5. Rajagopalan, S., Nepa, J. and Venkatachalam, S. (2012) Chromodomain helicase DNA-binding protein 2 affects the repair of X-ray and UV-induced DNA damage. Environ Mol Mutagen, 53, 44-50.
6. Marfella, C.G.A., Ohkawa, Y., Coles, A.H., Garlick, D.S., Jones, S.N. and Imbalzano, A.N. (2007) Mutation of the SNF2 family member Chd2 affects mouse development and survival. (vol 209, pg 162, 2006). J Cell Physiol, 212, 562-562.
7. Feys, T., Poppe, B., De Preter, K., Van Roy, N., Verhasselt, B., De Paepe, P., De Paepe, A. and Speleman, F. (2007) A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines. Haematol-Hematol J, 92, 913-920.

Figure Gallery

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About Chromatin Regulator

Chromatin Regulator Cistrome
is a unique database integrating curated information of CRs, CR ChIP-seq datasets, CR related HM ChIP-seq datasets, and analysis of the relationship between CRs and HMs ChIP-seq pairs in human and mouse.