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Nucleosome organization
The nucleosome organization regulates transcriptional activity by influencing the access of DNA-binding proteins to the genome and the elongation of RNA polymerase II. Micrococcal nuclease digestion followed by high-throughput sequencing (MNase-seq) is the most popular technology used to generate nucleosome organization maps on a genome-wide scale. The lack of comprehensive MNase-seq data management limits systematic explorations of the regulatory mechanisms involved in the nucleosome organization. NUCOME organizes 160 human and mouse samples for users.
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Data deposited in the NUCOME
NUCOME includes 37 human samples and 123 mouse samples of various cell and tissue types.The NUCOME describes the MNase-seq data based on several nucleosome organization features to help users assess the data usability. Users can acquire nucleosome organization information on a genome scale by downloading processed standard files for downstream analyses. In addition, users can query quantified nucleosome organization information at genome sites.
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Usage and Utility
NuP Browser module provides standard and nucleosome organization information in user uploaded genomic regions. TSS-centered Annotation module provides informative nucleosome organization features and nucleosome annotaions downstream TSS.TSS-centered Annotation module provides informative nucleosome organization features and nucleosome annotaions around DHS.
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